Dr. Yudong He, Scientific Director, Rosetta Inpharmatics to Present at GTCbio's 2nd Annual Rediscovering Biomarkers on July 10-11, 2008 in Boston, MA
Dr. Yudong He, Scientific Director, Rosetta Inpharmatics will be presenting at GTCbio's 2nd Annual Rediscovering Biomarkers on July 10-11, 2008 in Boston, MA. Dr. Hanash will present on "Biomarker Discovery: Lessons Learned."

/Science and Research News Articles/ - MONROVIA, CA, April 18, 2008 - Dr. Yudong He, Scientific Director, Rosetta Inpharmatics will be presenting at GTCbio's 2nd Annual Rediscovering Biomarkers on July 10-11, 2008 in Boston, MA. Dr. Hanash will present on "Biomarker Discovery: Lessons Learned."


Approaches to identifying molecular biomarkers and discovering mechanisms of action in biomedical research are evolving today, as the growing symbiosis with computational sciences becomes more widely appreciated. In fact, the combination of various new technologies has been pushing forward both frontiers. Here, we present examples of the combined use of in vivo siRNA knock-down technology, genome-wide gene expression profiling, and computational reasoning to unveil regulatory causal relationships and the sufficiency network of identified genes for compound-induced effects. Unlike previously reported approaches, our method requires only limited targeted perturbations for genome-wide de novo pathway discovery. Hence, our method can be directly applied to animal models in which it is still technically challenging to perform genome-wide genetic perturbation or RNAi screening. The independent application of our derived model to compounds with unrelated mechanisms of action suggests the existence of a universal molecular module that mediates a specific phenotype. When combined with phenotypic evaluation, our approach should help to unleash the full potential of siRNAs in systematically unveiling the molecular mechanisms of biological events.


The 2nd Annual Rediscovering Biomarkers Conference will exposes attendees to the latest advancements and developments in biomarkers and predictive medicine. Attendees will gain insight into discovery and development processes, hear about new biomarkers and upcoming trends in the industry, as well as the status of those in clinical trials. Delegates will also receive highly valuable information on tools for improving reimbursement strategies and the efficacy and validation of biomarkers.


For more information including a detailed agenda, exhibitor opportunities and registration information visit http://gtcbio.com/conferenceDetails.aspx?id=124
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